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KMID : 0360319870190020063
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Journal of Korean Cancer Research Association
1987 Volume.19 No. 2 p.63 ~ p.67
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Effects of Chemotherapeutic Agents and Polysaccharide-K Combination Therapy on Natural Killer Cell Activity in Stomach Cancer Patients
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정영환/Chung, Young-Hwan
김창민/이진오/강태웅/조성기/윤택구/Kim, Chang-Min/Lee, Jhin-Oh/Kang, Tae-Woong/Jo, Sung-Kee/Yun, Taik-Koo
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Abstract
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This study was performed to evaluate effects of chemotherapeutic agents and polysaccharide-K combination therapy on natural killer cell activity in 29 patients with inoperable stomach cancer.
Of total 29 patients, 9 patients received chemotherapy and krestin and 12 patients received chemotherapy and copolang.
In 8 control patients, only chemotherapy was given.
All groups showed the decreasing tendency in NK cell activity after 4 weeks´ treatment, but in contrast to control group, krestin and copolang group revealed the inclination to restore NK cell activity after 8 weeks´ treatment.
There was significant decrease in peripheral lymphocytes count after 8 weeks´ treatment.
No difference in clinical outcome was found during follow up periods among the groups.
We expect that the long-term administration of polysaccharide-K would give beneficial effects on inoperable patients with stomach cancer through the mechanism involving augmentation of NK cell activity.
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KEYWORD
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